GENOTOXICITY STUDIES OF p-DIMETHYLAMINOAZOBENZENE (DAB)
نویسندگان
چکیده
منابع مشابه
Genotoxicity studies OF p-dimethylaminoazobenzene (DAB).
The potential genotoxicity of the rodent liver carcinogen p-dimethylaminoazobenzene (DAB) was evaluated in compliance with the guidelines for genotoxicity studies of drugs (Notification No. 1604, Nov. 1, 1999, Ministry of Health and Welfare, Japan) and the OECD guidelines for testing chemicals. DAB was clearly positive in both the bacterial reverse mutation test (Ames test) and in vitro chromos...
متن کاملStudies on xanthine oxidase during carcinogenesis by p-dimethylaminoazobenzene.
Protein and riboflavin deficiencies (11, 17, 1, 7) seem to be major dietary factors involved in the production of liver cancers by feeding p-dimethylaminoazobenzene. The quantity and type of fat in the diet also appear to be important in this process (14, 18), and other dietary factors, such as biotin, play a role under certain conditions (8, 22). Con versely, a major effect of feeding p-dimeth...
متن کاملProtective effect of Nigella sativia seeds against dimethylaminoazobenzene (DAB) induced liver carcinogenesis
Liver cancer is one of the most common solid tumors worldwide. Extensive research was carried out to document the powerful properties of Nigella sativa (N. sativa) as an anti-tumor, bactericide, anticestode, antinematode, anti-inflammatory, analgesic, anti-diabetic and diuretic with many other uses. Little is known about the Nigella sativa anti-tumor property in liver cancers, thus our current ...
متن کاملThe numerical proportions of cell types in rat liver during carcinogenesis by 4-dimethylaminoazobenzene (DAB).
T h e l iver is a n o rgan wh ich is f r e q u e n t l y u t i l ized for b iochemica l i nves t i ga t i ons because of i ts la rge vo lume a n d i ts a p p a r e n t h o m o g e n e i t y . Ac tua l ly , t he l iver is n o t a h o m o g e n e o u s organ , since i t con ta ins , in a d d i t i o n to t he h e p a t i c cells, an app rec iab le n u m b e r of o the r cells t h e presence of wh...
متن کاملProtective action of an anti-oxidant (L-Ascorbic acid) against genotoxicity and cytotoxicity in mice during p-DAB-induced hepatocarcinogenesis.
BACKGROUND DNA damage from micronutrient deficiencies has been suggested as one major cause of cancer. Therefore studies involving vitamin supplementation, particularly with those with anti-oxidant activity, in combating cancer have routinely been carried out in both in vivo and in vitro systems, but relatively much less in mice. AIMS The present study examines if L-Ascorbic acid (AA; vitamin...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 2006
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.31.399